Steven G. NADLER,James K. TAMURA,Laura PRICE,Robert P. REHFUSS,Suzanne J. SUCHARD,Anish SURI,James William BRYSON,Aaron YAMNIUK,Steven GRANT,Olga IGNATOVICH,Philip DREW
申请号：
US14510474
公开号：
US20150023976A1
申请日:
2014.10.09
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The antibody polypeptides are useful in the treatment of diseases involving CD40L activation, such as graft-related diseases and autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VH or VK domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA) or another antigen.
