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AGENT DESTINÉ À TRAITER OU À SUPPRIMER UNE RÉCIDIVE DE LEUCÉMIE MYÉLOGÈNE AIGUË
专利权人:
RIKEN
发明人:
ISHIKAWA FUMIHIKO,SAITO YORIKO,HASHIZUME YOSHINOBU,KODA YASUKO,YUKI HITOMI
申请号:
EP13823379
公开号:
EP2878601A4
申请日:
2013.07.29
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
This invention relates to an agent for treating or inhibiting recurrence of acute myeloid leukemia and an agent for inhibiting growth of leukemia stem cells comprising a compound represented by formula (I) or a salt thereof: wherein Ar 1 and Ar 2 each represent aryl or heteroaryl; L represents O, S, NH, NHCO, or CONH; X represents CH or N; Y represents C 1-3 -alkylene; Z 1 represents hydrogen, C 1-6 -alkyl, amino-C 1-6 -alkyl, C 1-6 -alkylamino-C 1-6 -alkyl, di(C 1-6 -alkyl)amino-C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, or carboxy-C 1-6 -alkyl; and Z 2 represents C 1-6 -alkyl, amino-C 1-6 -alkyl, C 1-6 -alkylamino-C 1-6 -alkyl, di(C 1-6 -alkyl)amino-C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, or carboxy-C 1-6 -alkyl, Z 1 and Z 2 may, together with adjacent nitrogen, form a heterocyclic group containing as a ring member one or more hetero atoms, in addition to the nitrogen adjacent to Z 1 and Z 2 .
来源网站:
中国工程科技知识中心
来源网址:
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