Robert J. Bayer;Caryn Bowe;Shawn DeFrees;Krishnasamy Panneer-Selvam
发明人:
Shawn DeFrees,Robert J. Bayer,Caryn Bowe,Krishnasamy Panneer-Selvam
申请号：
US12851651
公开号：
US08632770B2
申请日:
2010.08.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
