SANDANAYAKA, VINCENT,GURNEY, MARK,SINGH, JASBIR,YU, PENG,BEDELL, LOUIS,MAMAT, BJORN,ZHAO, LEI,MISHRA, RAMA K
申请号：
NZ56678806
公开号：
NZ566788A
申请日:
2006.06.23
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Discloses is an aryl or hetero aryl compound of formula (I) where the substituents are as disclosed in the description. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament by inhibiting leukotriene A4 hydrolase useful in treating asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases (IBD) and psoriasis. Examples of compounds of formula (I) include: 5-BenzyI-2-[4-((R)-1-pyrrolidin-2-yImethoxy)-phenyl]-thiazole 5-BenzyI-2-[4-((S)-1-pyrrolidin-2-yImethoxy)-phenyI]-thiazoIe and (S)-2-[(3-Phenoxyphenoxy)ethyl]-piperidine -1-carboxylic acid tert-butyl ester.
