This disclosure describes, in one aspect, therapeutic methods that involve administering cell-permeable iron to a subject. In some cases, the cell-permeable iron may be co-administered to the subject with a chemotherapeutic agent or radiation treatment, each in an amount that, in combination with the other, is effective to ameliorate at least one symptom or clinical sign of the tumor. In other cases, the cell-permeable iron may be administered in an amount effective to inhibit angiogenesis.
