BRAUN,MARIE-GABRIELLE,布朗玛丽‐盖伯瑞,布朗瑪麗‐蓋伯瑞,ELLIOT,RICHARD,艾略特理查,HANAN,EMILY,哈南艾蜜莉,HEALD,ROBERT ANDREW,赫尔德罗伯 安卓,赫爾德羅伯 安卓,MACLEOD,CALUM,麦克理奥德卡农,麥克理奧德卡農,STABEN,STEVEN T.,史戴本史蒂芬 T
申请号：
TW108100214
公开号：
TW201936612A
申请日:
2016.07.01
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such PI3K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon PI3K dysregulation.本文說明具有磷酸肌醇-3激酶(PI3K)調節活性或功能之苯并氧氮呯噁唑啶酮化合物，其具有式I結構： 或其立體異構體、互變異構體或醫藥學上可接受之鹽，且該等苯并氧氮呯噁唑啶酮化合物具有本文中所說明之取代基及結構特徵。亦說明包括式I化合物之醫藥組合物及藥劑，以及將該等PI3K調節劑單獨及與其他治療劑組合用於治療PI3K失調介導或依賴其之疾病或病狀的方法。
