ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 158P1D7 PROTEINS

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专利权人:

AGENSYS; INC.;AGENSYS, INC.;SEATTLE GENETICS, INC.

发明人:

MORRISON, ROBERT, KENDALL,AN, ZILI,MORRISON, KAREN JANE, MEYRICK,SNYDER, JOSH,JIA, XIAO-CHI

申请号：

SG11201501286P

公开号：

SG11201501286PA

申请日:

2013.08.23

申请国别(地区):

SG

年份:

2015

代理人:

摘要：

The invention provides an antibody-drug conjugate comprising an anti-158P1D7 antibody or antigen binding fragment thereof conjugated to monomethyl auristatin E (MMAE), wherein the antibody or fragment thereof comprises a heavy chain variable region comprising an amino acid sequence at least 80% homologous to the heavy chain variable region amino acid sequence set forth in SEQ ID NO:7 and a light chain variable region comprising an amino acid sequence at least 80% homologous to the light chain variable region amino acid sequence set forth in SEQ ID NO:8.

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中国工程科技知识中心

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http://www.ckcest.cn/home/