Greg Stahler,Ananya Mitra,Joyce Huang,Dan Andersen,Alexander K. Arrow,David Moore
申请号：
US16581000
公开号：
US20200114162A1
申请日:
2019.09.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.
