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Persistent release of the pharmacological components of phenyl
专利权人:
MERCK SHARP AND DOHME CORP.
发明人:
VILLACAMPA RAMOS, JOSE DE JESUS MATEO,ULLOA, SERGIO R.,JUAREZ VARGAS, LUIS JAVIER
申请号:
PE2011001106
公开号:
PE20120075A1
申请日:
2007.06.01
申请国别(地区):
PE
年份:
2012
代理人:
摘要:
It refers to a kind of effective synthesis, including: (a) an active principle, such as 5-30% by weight as phenyl in a wide angle, contained in a matrix, in addition to one or more active principles, selected from antihistamines, analytical methods, anti-corrosion methods and non steroid antiviral agents, and released immediately; (b) a matrix or network of hydrolyzed polymers containing a mixture of hydroxypropylmethylcellulose of 20 to 70 per cent by total synthetic weight and cellulose table salts of 5 to 50 per cent by total synthetic weight;(c) an anti adhesive, such as polyvinyl chloride, having a particle size distribution of less than 20 microns in 0.1-10% of the particles, by weight, in addition to other former adhesives, such as lubricants, sliding agents or mixtures thereof; and (d) hydrolytic film coatings, including Loratadina or myocardial infarction Ingredients are released over a long period of time and can be administered orally and are useful in the treatment of colds, flu or allergies.SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: (A) UN PRINCIPIO ACTIVO TAL COMO FENILEFRINA EN UNA CANTIDA DE 5-30% EN PESO DE COMPOSICION TOTAL COMPRENDIDA EN UNA MATRIZ ADEMAS DE UNO O MAS PRINCIPIOS ACTIVOS SELECCIONADOS ENTRE ANTIHISTAMINICO, ANALGESICO, ANTIPIRETICO Y ANTIMFLAMATORIO NO ESTEROIDE DE LIBERACION INMEDIATA; (B) UNA MATRIZ O RED POLIMERICA HIDROFILICA QUE COMPRENDE UNA MEZCLA DE HIDROXIPROPILMETILCELULOSA EN LA CANTIDAD DE 20 A 70 % EN PESO DE LA COMPOSICION TOTAL Y SAL DE CARBOXIMETIL CELULOSA SODICA PRESENTE EN 5-50% EN PESO DE LA COMPOSICION TOTAL; (C) UN ANTIADHERENTE TAL COMO POLIVINILPIRROLIDONA CON UNA DISTRIBUCION DE TAMANO DE PARTICULA DE 90% DE PARTICULAS INFERIORES A 20 MICRONES EN LA PROPORCION DE 0.1-10% EN PESO DE LA COMPOSICION TOTAL ADEMAS DE OTROS EXCIPIENTES TALES COMO LUBRICANTES Y DESLIZANTES O MEZCLAS DE LOS MISMOS; (D) UN RECUBRIMIENTO DE PELICULA HIDROFILICO QUE COMPRENDE LORATADINA O DESLORATADINA. LA COMPOSICION ES
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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