The invention relates to a substrate with an electron donating surface, having metal particles on its surface, the metal particles including palladium and at least one metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of the metal particles is from about 0.001 to about 8 &mu；g/cm2. A method of manufacturing the substrate including the steps a) depositing metal particles from a suspension of metal particles onto the substrate, b) rising and c) drying.本發明揭示一種新基材，其使得可能將與生物相容性以及抗微生物性質有關之表面性質予以改良。該基材具有一推電子表面，其特徵為在該表面上具有金屬粒子，該等金屬粒子包括鈀及選自由金、釕、銠、鋨、銥及鉑組成之群的至少一金屬，其中該等金屬粒子之量為約0.001 μg/cm2至約8 μg/cm2。該基材被提議用於不同用途，諸如用於改良疏水性、蛋白質吸附、細菌黏附、組織內生、補體活化、發炎反應、血栓成形性(thrombogenicity)、摩擦係數及表面硬度，以及防止細菌傳染且尤其防止醫院感染。
