The Regents of the University of Colorado, a body corporate;Colleen COURTNEY;Anushree CHATTERJEE
发明人:
Anushree Chatterjee,Colleen Courtney
申请号：
US15546971
公开号：
US20180002692A1
申请日:
2016.02.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Described herein are RNA-based antisense therapeutics to target antibiotic resistant bacteria. The antisense therapeutics disclosed herein can be useful in re-sensitizing drug-resistant bacteria to antibiotics, as well as developing antibiotics that have bactericidal or bacteriostatic effects on the drug-resistant bacteria or are capable of preventing emergence of antibiotic resistance. Also described herein are methods for re-sensitizing a subject to one or more antibiotics in need thereof, methods for identifying target genes involved in adaptive antibiotic resistance in bacteria, and methods for developing antibacterial antisense therapeutics.
