Judith M. Gottwein,Maria Lisa Knudsen,Troels Kasper Høyer Scheel,Jens Bukh
申请号：
US13059130
公开号：
US08663653B2
申请日:
2009.07.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recovered 2b/2a recombinants from 2 transfection experiments revealed that 2b/2a was genetically stable. Conclusion: The developed 2b/2a viruses provide a robust in vitro tool for research in HCV genotype 2b, including vaccine studies and functional analysis.
