GALLAGHER, MICHELLE B.,BERG, MARK E.,SCHNEIDER, JENNIFER M.
申请号：
CA3032664
公开号：
CA3032664A1
申请日:
2017.06.29
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Bone-contacting surfaces and free surfaces of orthopedic implants. The implants are additively manufactured, followed by mechanical, chemical, or mechanical and chemical erosion. At least some of the surfaces of the implants include an osteoinducting roughness that has micro-scale structures and nano-scale structures that facilitate and enhance osteoinduction and osteogenesis, as well as enhanced alkaline phosphatase, osterix, and osteocalcin expression levels along the pathway of mesenchymal stem cell differentiation to osteoblasts.
