Stimulant and / or activator of soluble guanylate cyclase (sGC) in combination with an inhibitor of neutral endopeptidase (NEP inhibitor) and / or an angiotensin II antagonist and use thereof
The present invention relates to the treatment of cardiovascular disorders such as heart failure with retained ejection fraction or reduced ejection fraction heart failure, renal disorders such as chronic renal failure, urological disorders, lung disorders, central nervous system disorders and Fibrotic diseases and other disease symptoms (eg, end organ damage affecting the brain, kidney or heart) for prevention and / or for regulation of cerebral perfusion in the case of demented cerebrovascular conditions, for example The invention relates to stimulants and activators of soluble guanylate cyclase in combination with inhibitors of neutral endopeptidase and / or angiotensin II antagonists for the treatment and / or prophylaxis of and the use thereof.本発明は、心血管障害、例えば駆出率が保持されている心不全または駆出率が低下した心不全、腎障害、例えば慢性腎不全、泌尿器系障害、肺障害、中枢神経系の障害の処置および／または予防のための、例えば認知症の脳血管の状態の場合の脳灌流の調節のための、線維性疾患およびその他の疾患症状（例えば、脳、腎臓または心臓に影響を及ぼす終末器官損傷）の処置および／または予防のための中性エンドペプチダーゼの阻害剤および／またはアンジオテンシンII拮抗薬と組み合わせた可溶性グアニル酸シクラーゼの刺激薬および活性化薬ならびにその使用に関する。
