This invention, in order to become extinct the non tumor origin Characteristic and the tumor origin Characteristic cancer cell inside the target, the IL8 CXCR1 path inhibiter (for example, resistance - CXCR1 antibody or reperutakishin) independently, or jointly using with the additional chemotherapeutic agent, offers the manner which remedies the cancer by prescribing. In addition as for this invention, (for example,) it detects the existence of the solid tumor main stem cell of the patient on the basis of the existence of CXCR1 or FBXO21, those it offers also the constituent and manner in order to be isolated.本発明は、対象内の非腫瘍原性および腫瘍原性の癌細胞を死滅させるように、IL8-CXCR1経路阻害剤(例えば、抗-CXCR1抗体またはレペルタキシン)単独で、または追加の化学療法剤と併用して投与することによって、癌を治療する方法を提供する。本発明はまた、(例えば、CXCR1またはFBXO21の存在に基づいて)患者の固形腫瘍幹細胞の存在を検出し、それらを単離するための組成物および方法も提供する。
