The present invention relates to compounds and pharmaceutically acceptable saltsof Formulas A and B: (A) and (B) wherein A, B, R, R, R,R, R, R, R, R, Rand R are as defined above. The invention further relates to pharmaceuticalcompositions comprising the compounds and pharmaceutically acceptable saltsand to methods of treating diabetes mellitus and its complications, cancer,ischemia, inflammation, central nervous system disorders, cardiovascular disease,Alzheimer's disease and dermatological disase pression, virus diseases,inflammatory disorders, or diseases in which the liver is a target organ.