Cutaneous treatment apparatuses are provided that enhance percutaneous absorption of a treatment formulation. Related methods are also provided. In general, examples of the cutaneous treatment systems and/or apparatuses described herein are capable of attaching to a cutaneous surface and applying a treatment formulation to a localized cutaneous region. Embodiments of a cutaneous treatment apparatus generally include a heater and a treatment delivery component, including a treatment portion. The treatment portion includes a treatment formulation, including a therapeutic compound, and a treatment surface configured to contact the cutaneous region. The heater component is removably couplable with the treatment delivery component and is configured to transfer heat to the treatment portion. Upon heating, the therapeutic compound is configured to release from the treatment portion through the treatment surface towards the cutaneous region.
