Systems, kits and methods for transferring heat with a portion of a mammal are provided. Aspects of the subject systems include a negative pressure device configured to apply negative pressure to a portion of a mammal, and a temperature modulation device configured to contact the portion of the mammal under negative pressure in a manner sufficient to transfer heat with the contacted portion of the mammal, e.g., either remove heat or introduce heat into the contacted portion of the mammal. The disclosed systems and methods find use in a variety of different applications, including both therapeutic and non-therapeutic applications.
