It designates that the expedient which is effective to the remedy or prevention of the inflammation characteristic intestinal disease is offered as topic. The enzyme which possesses the ability to form oligosaccharide with in vivo was used, the enzyme composition for remedy or prevention of the inflammation characteristic intestinal disease is offered.炎症性腸疾患の治療又は予防に有効な手段を提供することを課題とする。生体内でオリゴ糖を生成する能力を有する酵素を用いた、炎症性腸疾患の治療又は予防用の酵素組成物が提供される。