Non-diffusive botulinum toxin causing local muscle paralysis, and purification method thereof

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专利权人:

Hyun Sub Lee;Yong Hoon Chung

发明人:

Yong Hoon Chung,Hyun Sub Lee

申请号：

US13700867

公开号：

US09598683B2

申请日:

2011.05.13

申请国别(地区):

US

年份:

2017

代理人:

摘要：

A method for purifying a non-spreading botulinum toxin that causes local muscle paralysis and a non-spreading botulinum toxin obtained thereby includes the steps of: subjecting a purified botulinum toxin type A product to ion-exchange chromatography using a controlled pH of buffer, concentration of sodium chloride (NaCl), thereby separating the botulinum toxin type A product into subfractions； and collecting a subfraction having an A260/A280 value in a specific range from the separated subfractions.

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中国工程科技知识中心

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