The present disclosure relates to hand, foot, and mouth disease vaccines and immunogenic compositions having one or more antigens from at least one virus that causes hand, foot, and mouth disease in humans, and methods of manufacture, formulation, and testing, and uses thereof.本發明係關於手、足及口病疫苗以及免疫原性組合物,其具有一或多種來自至少一種引起人類之手、足及口病的病毒之抗原;以及其製造、調配及測試的方法及用途。