novel 3- (4- (benzyloxy) phenyl) hex-4-ynoic acid derivative, method of preparation thereof and pharmaceutical composition for the prevention and treatment of metabolic diseases including it as an effective ingredient
CHANG MO SON,DAEHOON KIM,HAN KYU LEE,HYUNG-HO CHOI,JAE HYUN KIM,JAEKEOL RHEE,JIN WOONG KIM,JIN YANG,KYU HWAN LEE,TAE-YOUNG HA
申请号：
BR112015025072
公开号：
BR112015025072A2
申请日:
2014.04.17
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
"New 3- (4- (benzyloxy) phenyl) hex-4-yanoic acid derivative, method of preparation thereof and pharmaceutical composition for prevention and treatment of metabolic diseases including the same as an effective ingredient" The present invention relates to: to a novel 3- (4- (benzyloxy) phenyl) hex-4-yanoic acid derivative, a method of preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient for prevention and treatment of metabolic diseases. the novel 3- (4- (benzyloxy) phenyl) hex-4-ynoic acid derivative, an optical isomer thereof, or the pharmaceutically acceptable salt of the present invention has excellent activations in gpr40 protein activation and, accordingly, in promoting insulin secretion, but has no toxicity when given with other medicines. that is, the novel 3- (4- (benzyloxy) phenyl) hex-4-ynoic acid derivative, its optical isomer thereof or its pharmaceutically acceptable salt of the present invention may be administered in conjunction with other medicaments and can promote gpr40 protein activation significantly, so that the composition comprising the compound of the present invention as an active ingredient can be efficiently used as a pharmaceutical composition for the prevention and treatment of metabolic diseases such as obesity, type i diabetes, type ii diabetes, incompatible glucose tolerance, insulin resistance, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia, syndrome x, etc. 1/1resumo “novo derivado de ácido 3-(4-(benziloxi)fenil)hex-4-inóico, método de preparação do mesmo e composição farmacêutica para prevenção e tratamento de doenças metabólicas incluindo o mesmo como ingrediente eficaz” a presente invenção refere-se a um novo derivado de ácido 3-(4-(benziloxi)fenil)hex-4-inóico, um método de preparação do mesmo, e uma composição farmacêutica compreendendo o mesmo como ingrediente ativo para prevenção e tratamento de doenças metabólicas. o novo derivado de ácido 3
