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Mangiferin-containing skin-care compositions and methods
专利权人:
Idowu Olusola Clement
发明人:
申请号:
GB201811143
公开号:
GB201811143D0
申请日:
2018.07.06
申请国别(地区):
GB
年份:
2018
代理人:
摘要:
An additive for a skin care composition, wherein the additive comprises a complex of mangiferin with β-cyclodextrin or a β-cyclodextrin derivative is provided. Preferably the β-cyclodextrin derivative is selected from hydroxypropyl-β-cyclodextrin, sulfobutylether β-cyclodextrin and mono(6-ethylene-diamino-6-deoxy)-β-cyclodextrin. The mangiferin-β-cyclodextrin complex preferably has a stoichiometric ratio of 1:1. The mangiferin-β-cyclodextrin additive is preferably for the prevention of UV-induced mitochondrial DNA (mtDNA) damage. A skin care composition comprising a mangiferin-β-cyclodextrin additive is also outlined wherein preferably the additive is included in the composition such that the concentration of the mangiferin in the composition is from 1 to 10% (w/w). preferably the composition is in the form of an emulsion where the mangiferin-β-cyclodextrin complex is in an aqueous phase. The skin care composition may further comprise at least one additional ingredient selected from an organic UV filter, an inorganic UV filter, an emulsifier, a suspending agent, a film former and a skin conditioner. A method of preparing a mangiferin-β-cyclodextrin additive is provided comprising: (i) preparing a solution of β-cyclodextrin or β-cyclodextrin derivative in water; (ii) adding mangiferin to the solution; (iii) allowing the complex to form at a temperature of between 30oC and 50oC for between 3 to 6 hours; and (iv) removing solids by filtration.
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