Nucleic acid encoding GPC3 chimeric antigen receptor protein and T lymphocytes expressing GPC3 chimeric antigen receptor protein

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专利权人:

科済生物医薬（上海）有限公司;科済生物医薬(上海)有限公司

发明人:

李 宗海,高 慧萍,蒋 華,石 必枝,王 華茂,李 克桑,王 紅陽,楊 勝利,顧 健人

申请号：

JP2016512212

公开号：

JP6426713B2

申请日:

2014.05.06

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

A nucleic acid encoding a chimeric antigen receptor expressed at surface of a T lymphocyte, said chimeric antigen receptor comprises, connected in the order of, an extracellular binding domain, a transmembrane region, and an intracellular signaling domain, wherein the extracellular binding domain comprises a single chain antibody, scFv(GPC3), which specifically recognizes the C-terminal epitope of GPC3. A genetically modified T lymphocyte having a chimeric antigen receptor expressed at surface thereof, and the chimeric antigen receptor is expressed by the nucleic acid described above.

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