IADONATO, SHAWN P.,萧恩P 伊亚当图,蕭恩P 伊亞當圖,MAGNESS, CHARLES L.,查尔斯L 麦格尼斯,查爾斯L 麥格尼斯,BRANUM, MARK,马克 布拉南,馬克 布拉南,MCVEAN, MARALEE,玛拉里 麦维恩,瑪拉里 麥維恩,SCHERER, CHRISTINA A.,克莉斯汀娜 薛尔,克莉斯汀娜 薛爾
申请号：
TW095141982
公开号：
TWI465460B
申请日:
2006.11.13
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention.本發明描述用於治療病毒感染及癌症之新穎醫藥組合物。該等醫藥組合物包括具有增強之細胞滲透性、降低之氧化潛力、改良之抗病毒活性、改良之酶活性或無酶活性之突變寡腺苷酸合成酶(OAS)。該等醫藥組合物具有改良之藥物特性,且保留或具有相對於其天然形式之增強之抗病毒活性。該等醫藥組合物進一步包括經化學修飾之寡腺苷酸合成酶,該等化學修飾經設計以於活體內增加血清穩定性並降低免疫原性。該等化學修飾進一步增加藥物活體外穩定性及可製造性。本發明描述包含九十種以上新穎修飾之組合物。本發明亦描述本發明多肽之抗體。
