The present disclosure describe inhalation particles where each discreteunagglomerated inhalation particle comprising 2 or more active pharmaceuticalingredients. In one embodiment, the inhalation particles comprise a first anda second API where the second API covers, at least partially, and protects thefirst API from degradation or instability. Inhalation particles comprising afirst and a second API as described herein have many advantages over presentmeans of delivering two or more APIs. Formulations comprising such inhalationparticles are also described.