Radiopaque, water-insoluble, poly (vinyl alcohol) iodinated benzyl ethers, method of preparation, injectable embolizing compositions containing the same and use thereof.

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专利权人:

ANTIA THERAPEUTICS S.A.;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL)

发明人:

CORALIE NYFFENEGGER,ERIC DOELKER,GERT ANDERSEN,GÉRALDINE AUGUSTI,OLIVIER JORDAN,YVES CHEVALIER

申请号：

BR112012019754

公开号：

BR112012019754A2

申请日:

2011.03.09

申请国别(地区):

BR

年份:

2016

代理人:

摘要：

Radiopaque, water-insoluble, poly (vinyl alcohol) iodinated benzyl ethers, method of preparation, injectable embolizing compositions containing the same and use thereof. The invention relates to a non-biodegradable, water-insoluble radiopaque polyvinyl alcohol benzylether consisting of a pva having covalently grazed therein benzyl groups comprising 1-4 iodine atoms per benzyl group, a process for the preparation thereof iodine comprising 1-4 iodine atoms per benzyl group in a polar aprotic solvent in the presence of a base under anhydrous conditions. said iodized ipva benzylether is particularly useful as an embolic agent in an embolizing injectable composition. The invention also relates to an embolizing injectable composition comprising said iodinated pva benzyl ether and capable of forming a cohesive mass in contact with a body fluid by precipitation of the iodized pva benzyl ether. said injectable embolizing composition is particularly useful for in situ formation of a cohesive mass in a blood vessel or a tumor. The invention further relates to a coating composition containing said iodinated pva benzylether and capable of forming a radiopaque coating on a medical device. The invention further relates to particles formed from said iodinated pva benzylether.éteres benzílicos iodados de poli (álcool vinílico) radiopacos, não biodegradáveis, insolúveis em água, método de preparação, composições embolizantes injetáveis contendo o mesmo e utilização do mesmo. a invenção diz respeito a um benziléter de poli (álcool vinílico) radiopaco, não biodegradável, insolúvel em água consistindo de um pva tendo covalentemente graftizados nela grupos benzila iodados compreendendo 1-4 átomos de iodo por grupo benzila, um processo para a preparação do mesmo iodado compreendendo 1-4 átomos de iodo por grupo benzila em um solvente polar aprótico, na presença de uma base em condições anidras. o referido benziléter de ipva iodado é particularmente útil como agente embólico em uma composi

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