ANTI-CD74 ANTIBODY CONJUGATES COMPOSITIONS COMPRISING ANTI-CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES

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专利权人:

发明人:

STAFFORD RYAN,YAM ALICE,GILL AVINASH,PENTA KALYANI,LI XIAOFAN,SATO AARON

申请号：

IN201847031094

公开号：

IN201847031094A

申请日:

2018.08.20

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

Provided herein are antibody conjugates with binding specificity for CD74 wherein the antibody comprises a non-natural amino acid at a site selected from the group consisting of HC-F404 HC-K121 HC-Y180 HC-F241 HC-221 LC-T22 LC-S7 LC-N152 LC-K42 LC- E161 LC-D170 HC-S136 HC-S25 HC-A40 HC-S119 HC-S190 HC-K222 HC-R19 HC-Y52 or HC-S70 according to the Kabat Chothia or EU numbering scheme and compositions comprising the antibody conjugates including pharmaceutical compositions methods of producing the conjugates and methods of using the conjugates and compositions for therapy.

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