DIRECT DISSOLUTION OF DOCETAXEL IN A SOLVENT IN POLYSORBATE 80

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专利权人:

AVENTIS PHARMA S.A.

发明人:

NAKACH, MOSTAFA,AUTHELIN, JEAN-RENE,DIDIER, ERIC,FOUQUE, ELIE

申请号：

NZ58163408

公开号：

NZ581634A

申请日:

2008.06.06

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a process for the preparation of a solution of docetaxel in polysorbate 80, wherein the docetaxel is dissolved in an organic solvent having a boiling point of between 40 and 153°C, in particular acetone, acetonitrile, methylene chloride or DMF, with the exception of ethanol, the solution obtained is mixed with polysorbate 80 and the dissolution solvent is evaporated under reduced pressure.

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