您的位置: 首页 > 农业专利 > 详情页

Quinoline-8-sulfonamide derivatives that have an anticancer activity
专利权人:
Agios Pharmaceuticals; Inc.
发明人:
SAUNDERS, Jeffrey,SALITURO, Francesco,YAN, Shunqi
申请号:
ES10794668
公开号:
ES2632954T3
申请日:
2010.06.29
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (II) or a pharmaceutically acceptable salt thereof, wherein: ** Formula ** W, X, Y and Z are each independently selected from CH or N; D and D1 are independently selected from a link or NRb; L is a bond, -C (O) -, - (CRcRc) m-, -OC (O) -, - (CRcRc) m-OC (O) -, - (CRcRc) mC (O) -, -NRbC (S) - or -NRbC (O) -; R1 is selected from alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl; each of which is substituted with 0-5 occurrences of Rd; each R3 is independently selected from halo, haloalkyl, alkyl, hydroxyl and -ORa; each Ra is independently selected from alkyl, acyl, hydroxyalkyl and haloalkyl; each Rb is independently selected from hydrogen and alkyl; each Rc is independently selected from hydrogen, halo, alkyl, alkoxy and halo alkoxy or two Rc taken together with the carbon atoms to which they are attached form an optionally substituted cycloalkyl; each Rd is independently selected from halo, haloalkyl, haloalkoxy, alkyl, alkynyl, nitro, cyano, hydroxyl, -C (O) Ra, -OC (O) Ra, -C (O) ORa, -SRa, -NRaRb and - ORa, or two Rd taken together with the carbon atoms to which they are attached form an optionally substituted heterocyclyl; n is 0, 1 or 2; m is 1, 2 or 3; h is 1; and g is 1.Un compuesto de fórmula (II) o una sal farmacéuticamente aceptable del mismo, en donde:**Fórmula** W, X, Y y Z se seleccionan cada uno independientemente entre CH o N; D y D1 se seleccionan independientemente entre un enlace o NRb; L es un enlace, -C(O)-, -(CRcRc)m-, -OC(O)-, -(CRcRc)m-OC(O)-, -(CRcRc)m-C(O)-, -NRbC(S)- o -NRbC(O)-; R1 se selecciona entre alquilo, cicloalquilo, arilo, heteroarilo y heterociclilo; cada uno de los cuales está sustituido con 0-5 apariciones de Rd; cada R3 se selecciona independientemente entre halo, haloalquilo, alquilo, hidroxilo y -ORa; cada Ra se selecciona independientemente entre alquilo, acilo, hidroxialquilo y haloalquilo; cada Rb se selecciona independientemente entre hidrógeno y alquilo; cada Rc se selecciona independientemente
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充