Dana-Farber Cancer Institute, Inc.;Massachusetts Institute of Technology
发明人:
Michael Solomon Goldberg,Daniela Schmid,Darrell J. Irvine,Kai Wucherpfennig
申请号：
US16065489
公开号：
US20180369407A1
申请日:
2016.12.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure provides particles with a polymeric core containing a pharmaceutically active agent； and an antibody fragment conjugated to the surface of the particle, wherein the antibody fragment targets an endogenous immune cell subset (e.g., an endogenous T-cell or a myeloid-derived suppressor cell). The present invention provides methods for forming and methods for using the particles. The particles described herein may be useful in treating and/or preventing proliferative disease, inflammatory disease, or neoplastic disorders (e.g., cancer, autoimmune diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a particle described herein.
