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Stabilized glucagon solutions
专利权人:
Solomon S. Steiner
发明人:
Solomon S. Steiner,Robert Hauser,Ming Li,Robert Feldstein,Roderike Pohl
申请号:
US12891240
公开号:
US09610329B2
申请日:
2010.09.27
申请国别(地区):
US
年份:
2017
代理人:
摘要:
A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.
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