STRUCTURE-BASED PEPTIDE INHIBITORS OF ALPHA-SYNUCLEIN AGGREGATION

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专利权人:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人:

David S. Eisenberg,Smriti Sangwan,Lin Jiang

申请号：

US16311593

公开号：

US20190241613A1

申请日:

2017.06.29

申请国别(地区):

US

年份:

2019

代理人:

摘要：

This invention relates to inhibitory peptides which bind to α-synuclein molecules and inhibit α-synuclein amyloidogenic aggregation, α-synuclein cytotoxicity, and spread of α-synuclein. Methods of making and using the inhibitory peptides (e.g. to treat subjects having conditions or diseases that are mediated by α-synuclein, such as Parkinson's disease, dementia with Lewy bodies, or MSA) are described.

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