Danforth P Miller;David Lechuga-Ballesteros;Reinhard Vehring
发明人:
Reinhard Vehring,Danforth P Miller,David Lechuga-Ballesteros
申请号：
US12953259
公开号：
US08668934B2
申请日:
2010.11.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more soluble in water than the active agent. The first and second solvents are removed from the solution to produce particles comprising the active agent and the excipient. In one version, the excipient comprises an amino acid and/or a phospholipid. A pharmaceutical formulation made by a version of the invention comprises particles comprising an active agent and an excipient which at least partially encapsulates the active agent, wherein the excipient is more soluble in water than the active agent.
