Donald Rao,Zhaohui Wang,John J. Nemunaitis,Neil Senzer
申请号：
US15141280
公开号：
US20160333351A1
申请日:
2016.04.28
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention includes compositions and methods for making and using a bifunctional shRNAs capable of reducing an expression of a K-ras gene, e.g., a mutated K-ras gene, wherein at least one target site sequence of the bifunctional RNA molecule is located within the K-ras gene and wherein the bifunctional RNA molecule is capable of activating a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of K-ras.
