The present invention provides a kind of novel liquid compositions, suitable for store system is formed in situ, to convey protein or peptide with controlled manner. Composition of the invention includes: (one) hydrophobic non-polymeric carrier material (2) biocompatible organic solvent dissolution hydrophobic, non-polymeric material those of miscible with water (3) compound that protein or peptide are covalently conjugated one or more formulas and improve results. The present invention also provides a kind of methods for manufacturing and using the composition.