Devices and methods for treating carpal tunnel syndrome or DeQuervain's syndrome. The device may include a resting portion for receiving a user's forearm, first and second contact portions configured to contact the user's forearm, and a stretching mechanism configured to apply opposing forces to the first contact portion and the second contact portion to stretch the user's underlying tissue. The first contact portion may be configured to apply a compressive force to the user's forearm at a first location. The second contact portion may be configured to apply a compressive force to the user's forearm at a second location different than the first location.