A method of monitoring blood glucose levels comprises obtaining a blood glucose reference sample measurement from a patient while monitoring a blood glucose level in said patient by processing signals from a continuous blood glucose sensor. The method further comprises determining a time for obtaining a subsequent blood glucose reference sample from said patient based, at least in part, on an indicator indicative of a reliability of said continuous blood glucose sensor and providing an operator or attendant an option to extend the time for obtaining the subsequent blood glucose reference sample measurement in response to a duration that an observed blood glucose level of said patient has been in a target range.La présente invention concerne la surveillance et/ou la régulation de niveaux de glycémie chez des patients. En particulier, des durées d'obtention d'échantillons de glycémie mesurée chez un patient peuvent être modifiées, au moins en partie, sur la base d'un niveau de glycémie dudit patient observé à partir d'un capteur de glycémie.