The present invention relates to a pharmaceutical composition for cartilage regeneration, pain suppression, and edema suppression, and more particularly, to a drug composition, comprising herbal extracts of Chaenomelis Fructus, Achyranthis Radix, Acanthopanax, Cinnamomi Cortex, Gentianae Radix, Clematidis Radix, Angelicae Radix, Cnidii Rhizoma, Gastrodiae Rhizoma, Safflower, Rhlomidis Radix, and Ledebouriellae Radix as active ingredients, which has no significant adverse side effects, suppresses pain and edema, and is effective in cartilage regeneration, thus is applicable in medicines, health foods, food additive or feed additives.