Methods and compositions for increasing the activity of inhibitory RNA

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专利权人:

Paul Chang

发明人:

Paul Chang,Anthony Leung,Phillip A. Sharp

申请号：

US12821967

公开号：

US08435961B2

申请日:

2010.06.23

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The invention provides methods for increasing the activity of an inhibitory RNA (RNAi) in a subject requiring administering one or more poly-ADP-ribose polymerase (PARP) inhibitors and/or one or more PARG activators to the subject. The invention also provides methods for increasing the activity of an inhibitory RNA in a cell or cell population requiring contacting a cell or cell population with one or more PARP inhibitors and/or one or more PARG activators. The invention further provides compositions and kits containing one or more PARP inhibitors and/or one or more PARG activators.

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