Alla Pritsker,Patrick Grailhe,Alexey Rak,Magali Mathieu,Christopher Ryan Morgan,Nicolas Baurin,Bruno Poirier,Cyril Daveu,Francis Duffieux,Han Li,Dorothea Kominos,Philip Janiak
申请号：
US14911429
公开号：
US09845363B2
申请日:
2014.08.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides antibodies that specifically bind to Plasminogen Activator Inhibitor type-1 (PAI-1), The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.
