Mark W. Grinstaff,Jesse Wolinsky,Stefan Yohe,Jonah Andrew Kaplan,Eric John Falde,Joseph Steven Hersey
申请号：
US14233570
公开号：
US20150037375A1
申请日:
2012.07.19
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided herein are 3-dimensional drug-eluting materials comprising biodegradable polymer(s), one or more bioactive agents and entrapped air. Various embodiments of the methods and compositions described herein are based, in part, on the discovery of hydrophobic doping agents that can be used in the manufacture of polymeric drug delivery compositions that permit the encapsulation of air, thereby permitting tunable drug release via controlled air removal. Such compositions are particularly useful for delivering therapeutically effective doses of one or more bioactive agents to a subject over an extended period of time (e.g., days, weeks, or months).
