Maria Aricò;Brunella Brunelli;Maurizio Comanducci;Mariagrazia Pizza;Silvana Savino;Maria Scarselli
发明人:
Maria Aricò,Brunella Brunelli,Maurizio Comanducci,Mariagrazia Pizza,Silvana Savino,Maria Scarselli
申请号：
US13806743
公开号：
US10478483B2
申请日:
2011.06.24
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence.
