Blood purification apparatus, method for determining transmembrane pressure difference of blood purification membrane, method for determining, apparatus and program
The leakage amount of albumin in the blood is controlled while suppressing the leakage of albumin in the blood when the blood is purified by the blood purification membrane. The blood purification device 1 has a control means for controlling the transmembrane pressure difference of the blood purification membrane of the blood purifier. The control means expresses the relationship between the transmembrane pressure difference P(Tn) and the solute leakage concentration N(Tn) of the predetermined solute in the blood at one or more predetermined times Tn after the start of blood purification, and the function Fn of the following equation. N(Tn) = Fn(P(Tn), Tn) (n is an integer of 1 or more) The transmembrane pressure difference Pa(Tn) corresponding to the target solute leakage concentration Na(Tn) at one or more predetermined time points Tn is determined based on the Control the transmembrane pressure difference of.血液が血液浄化膜で浄化される際の血中のアルブミンの漏出を抑制しつつ、そのアルブミンの漏出量を制御する。血液浄化装置１は、血液浄化器の血液浄化膜の膜間差圧を制御する制御手段を有する。制御手段が、血液浄化開始後の１つ以上の所定時刻Tnにおける膜間差圧P(Tn)と血中の所定溶質の溶質漏出濃度N(Tn)の関係を示す次式の関数Fn N(Tn) = Fn(P(Tn), Tn)（nは１以上の整数）に基づき、１つ以上の各所定時刻Tnにおける目標の溶質漏出濃度Na(Tn)に対応する膜間差圧Pa(Tn)を求め、その膜間差圧Pa(Tn)に基づいて血液浄化時の膜間差圧を制御する。
