St. Jude Children's Research Hospital;St. Jude Childrens Research Hospital
发明人:
Workman, Creg,Vignali, Dario,Collison, Lauren,Vignali, Kate
申请号：
AU2007298571
公开号：
AU2007298571B2
申请日:
2007.09.24
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35 -specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.
