The present disclosure relates to the injection composition containing acetaminophen, the injection composition comprising acetaminophen mixed in 0.01-5 wt %, a solubilizer mixed in 0.01-10 wt %, a toxicity inhibitor mixed in 0.05-5 wt %, an isotonic agent mixed in 0.1-10 wt %, an antioxidant mixed in 0.001-5 wt %, and the balance sterile purified water for injection.