SPITS, Hergen,BEAUMONT, Tim,YASUDA, Etsuko,KWAKKENBOS, Mark Jeroen
申请号：
ES08766756
公开号：
ES2575129T3
申请日:
2008.05.30
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
An isolated antibody or functional part thereof that is capable of specifically binding with the respiratory syncytial virus (VSR) F antigen, and in which the antibody or functional part thereof comprises: a. a heavy chain complementarity determining region (CDR) 1 comprising the amino acid sequence NYIIN (SEQ ID NO: 1), a heavy chain CDR2 comprising the amino acid sequence GIIPVLGTVHYAPKFQG (SEQ ID NO: 2), a CDR3 of heavy chain comprising the amino acid sequence ETALVVSTTYLPHYFDN (SEQ ID NO: 3), a light chain CDR1 comprising the amino acid sequence QASQDIVNYLN (SEQ ID NO: 4), a light chain CDR2 comprising the amino acid sequence VASNLET ( SEQ ID NO: 5), and a light chain CDR3 comprising the amino acid sequence QQYDNLP (SEQ ID NO: 6)； or b. a heavy chain CDR 1 comprising the amino acid sequence GFSFSHYA (SEQ ID NO: 73), a heavy chain CDR2 comprising the amino acid sequence ISYDGENT (SEQ ID NO: 74), a heavy chain CDR3 comprising the sequence amino acid ARDRIVDDYYYYGMDV (SEQ ID NO: 75), a light chain CDR1 comprising the amino acid sequence QDIKKY (SEQ ID NO: 76), a light chain CDR2 comprising the amino acid sequence DAS and a light chain CDR3 which comprises the amino acid sequence QQYDNLPPLT (SEQ ID NO: 77)； or c. a heavy chain CDR 1 comprising the amino acid sequence GFTFSSYN (SEQ ID NO: 80), a heavy chain CDR2 comprising the amino acid sequence ISAGSSYI (SEQ ID NO: 81), a heavy chain CDR3 comprising the sequence Amino acid AREDYGPGNYYSPNWFDP (SEQ ID NO: 82), a light chain CDR1 comprising the amino acid sequence SSNIGAGYD (SEQ ID NO: 83), a light chain CDR2 comprising the GNT amino acid sequence and a light chain CDR3 comprises the amino acid sequence HSYDRSLSG (SEQ ID NO: 84)； or d. a heavy chain CDR 1 comprising the amino acid sequence GFNFHNYG (SEQ ID NO: 87), a heavy chain CDR2 comprising the amino acid sequence VWYDGSKK (SEQ ID NO: 88), a heavy chain CDR3 comprising the sequence of amino acids VRDKVGPTPYFDS (SEQ ID NO: 89), a light chain CDR1 comprising the NIG
