A nasogastric/orogastric (Ng/Og) device includes a main lumen configured for at least one of gastric decompression, enteral feeding and enteral medication administration. An expandable esophageal cuff is carried by the device body and configured in a normally expanded position such that when inserted within the esophagus, the esophageal cuff conforms to the interior surface of the esophagus and emesis and/or reflux is blocked from passing out of the stomach and past the esophageal cuff. A vacuum lumen is carried by the device body and connected to the expandable esophageal cuff. When vacuum is applied, the esophageal cuff is contracted against the device body to permit the device to be inserted and placed within the esophagus. When the vacuum is released, the esophageal cuff expands against the interior surface of the esophagus.
