A cleaning system for controlling indoor harmful substances comprising a housing containing a controlling device to operate the cleaning system an atomization device atomizing the cleaning liquid and an air circulation device generating vortex flow to carry the atomized cleaning liquid for indoor circulation, wherein the counterforce of the vortex flow is sent to the inlet of the air circulation device. The cleaning system for controlling harmful substance in the present invention provides multiple advantages which can effectively incorporate large-areal disinfection, sterilization and sterilization by comprehensively transferring the atomized leaning liquid to every corner of the space through the air circulation device and improve the cleaning effectiveness. Meanwhile, the cleaning system in the present invention can be arranged with a remote controlling device so that users can focus on cleaning the local infected area without directly contacting the infected areas so as to reduce the risk of exposing users to the infected space.
