KANOUNI, TOUFIKE,卡由尼 塔法克,卡由尼 塔法克,LAWSON, JOHN D.,罗森 约翰D,羅森 約翰D,WALLACE, MICHAEL B.,瓦勒斯 麦克B,瓦勒斯 麥克B,DONG, QING,董庆,董慶
申请号：
TW099135319
公开号：
TW201215606A
申请日:
2010.10.15
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
Disclosed are JAK inhibitors of formula Iwhere G1, R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. Also disclosed are pharmaceutical compositions, kits and articles of manufacture which contain the compounds, methods and materials for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other diseases, disorders or conditions associated with JAK.所揭露者具有結構式I之JAK抑制劑其中G1、R1、R2、R3、R4、R5、R6與R7於說明書中定義。亦揭露的是醫藥組成物、套組與製造的技術論文,其包含作為製造所述化合物之化合物、方法以及材料,以及使用所述化合物以治療疾病、失調與症狀的方法,該疾病、失調與症狀涉及免疫與發炎反應,包括類風濕性關節炎、血液惡性腫瘤、類上皮癌(即,惡性腫瘤)以及其他與JAK相關連的疾病、失調與症狀。
